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Updated: Jul 12, 2025

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MiR-151a:一种强大的内源控制,用于在人类癌症中使小细胞外囊泡载荷正常化

Miranda Burdiel1,2, Julia Jiménez1,2, Carlos Rodríguez-Antolín1,2

  • 1Biomarkers and Experimental Therapeutics in Cancer, IdiPAZ, Madrid, Spain.

Biomarker research
|October 20, 2023
PubMed
概括

研究人员确定miR-151a作为一个可靠的正常化器量化微RNAs (miRNAs) 在小细胞外囊泡 (sEVs). 这一发现改善了癌症液体活检的标准化,为患者的诊断和监测提供了更一致的结果.

关键词:
在液体活检中的miRNA内源控制.miRNAs标准化的标准化sEVs 的使用情况.

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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