鼻腔通风功能在儿童阻塞性睡眠呼吸暂停综合征中的作用
Ying Pang1,2,3,4,5, Ling Xiao1,2,3,4,5, Jia Liang1,2,3,4,5
1Department of Otolaryngology, Children's Hospital of Chongqing Medical University, Chongqing, China.
Ear, nose, & throat journal
|October 21, 2023
概括
鼻通风功能可能是儿科阻塞性睡眠呼吸暂停综合征 (OSAS) 的关键. 患有OSAS的儿童表现出更高的鼻腔抵抗和更小的鼻腔体积,随着治疗改善.
科学领域:
- 儿科耳鼻喉科 儿科耳鼻喉科
- 睡眠医学 睡眠医学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 在儿童中增加的鼻腔抵抗 (NR) 和阻塞性睡眠呼吸暂停综合征 (OSAS) 之间的联系是有争议的.
- 研究鼻腔通风功能 (NVF) 对于理解OSAS病变的产生至关重要.
- 这项研究侧重于NVF在儿科OSAS中的病原遗传作用.
研究的目的:
- 在被诊断患有阻塞性睡眠呼吸暂停综合征 (OSAS) 的儿童中评估鼻通风功能 (NVF).
- 确定NVF在儿科OSAS发展中的潜在病原遗传作用.
- 评估结合内皮质固醇和口服蒙特卢卡斯特治疗对患有OSAS的儿童NVF参数的影响.
主要方法:
- 招募了109名患有OSAS的儿童和116名对照人进行多睡眠学 (PSG),NR和声学鼻测 (AR) 测量.
- 对90名患有轻度至中度OSAS的儿童进行了为期12周的联合治疗 (鼻内皮质类固醇 + 口服蒙特卢卡斯特).
- 治疗前后的桃腺体大小,PSG,NR和AR的比较. 在响应者和不响应者中.
主要成果:
- 与对照组相比,患有OSAS的儿童呈现出明显更高的NR和更小的鼻腔最小截面面积 (NMCA),鼻腔体积 (NCV) 和鼻体积 (NPV).
- 84.1%的儿童对12周的治疗有反应;58名儿童在NR,NMCA和NCV方面显著改善.
- 32名儿童的有效治疗与桃体腺体大小的减少以及NR和AR的变化相关;26名儿童改善了NVF而没有桃体腺变化.
结论:
- 鼻通风功能 (NVF) 似乎在儿科阻塞性睡眠呼吸暂停综合征 (OSAS) 中起着重要的病原学作用.
- 针对鼻炎和阻塞的治疗可以改善患有OSAS的儿童的NVF参数.
- 需要进一步的研究来阐明鼻子因素和儿童的OSAS之间的复杂相互作用.
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