用可植入的迷走神经刺激剂治疗的狗的长期结果

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Thomas R Harcourt-Brown¹, Michael Carter²

¹Langford Vets, University of Bristol School of Veterinary Sciences, Bristol, UK.

Journal of veterinary internal medicine

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概括

神经刺激剂 (VNS) 降低了发作频率,增加了狗的无发作间隔,尽管许多狗没有长期生存. 需要进一步的研究来证实这些发现.

科学领域:

兽医神经学兽医神经学
神经外科神经外科
的研究研究.

背景情况:

迷走神经刺激剂 (VNS) 对犬的长期疗效尚未评估.
狗的异形性是一种重大的临床挑战,通常需要先进的治疗方式.

研究的目的:

评估VNS植入对抗药性的狗发作频率的长期影响.
评估VNS植入后发作频率和间隔的变化.

主要方法:

一项不受控制的,开放的,前后研究,涉及12只患有耐火性异常性的客户拥有的狗.
在植入前6个月和植入后12个月保持了日记,以比较结果.
关键指标包括每月发作频率,发作间隔和发作自由率.

主要成果:

在12只狗中,有5只在植入后12个月前安乐死.
其余7只狗的发作频率下降了>50%,发作间隔增加了>3倍.
在这些7只狗中,有3只在最后的随访中实现了超过3个月的无发作状态.

结论:

植入VNS导致每月发作频率降低,狗的发作间隔增加,植入后2-3年特别明显.
很大一部分狗没有生存到体验这些长期益处,突出了潜在的局限性.
未来的临床试验是必要的,以确定因果关系和量化VNS在犬管理中的有效性.

关键词:

狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗是一种.发作发作这些迷走神经是一种神经.

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