截断的Dyrk1A通过抑制ASF介导的Bcl-x外因子2b纳入而加剧神经元亡

Shuqiang Zhang1,2, Junjie Zhong2,3,4, Lian Xu2,5

  • 1College of Life Sciences, Henan Normal University, Xinxiang, China.

PubMed
概括

双特异性和氨酸酸化调节的蛋白激酶1A (Dyrk1A) 通过抑制Bcl-xL表达来促进阿尔茨海默病中的神经元亡. 截断的Dyrk1A会加剧这种效应,导致疾病的进展.

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