苏玛克补充剂对脂质特征的影响:随机对照试验的系统审查和元分析
Hossein Bahari1,2, Shaghayegh Taheri3, Zahra Namkhah1
1Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Phytotherapy research : PTR
|October 21, 2023
概括
补充 Sumac 可以显著降低有害的胆固醇和甘油三,同时增加有益的 HDL 胆固醇. 较长的干预时间和较低的剂量 (低于3g) 显示出增强的降脂效果.
科学领域:
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 脱脂症是心血管疾病的主要危险因素.
- 饮食干预对于管理脂质概况至关重要.
- (Rhus coriaria) 是一种具有潜在治疗功能的香料.
研究的目的:
- 系统地审查和综合证据,关于补充果对脂质特征的影响.
- 为了评估果对总胆固醇,甘油三,LDL-C和HDL-C的影响.
- 探索影响苏玛克疗效的因素,如干预时间和剂量.
主要方法:
- 在PubMed,Scopus和Web of Science的系统文献搜索到2023年3月.
- 包括随机对照试验 (RCT),涉及成年参与者食用sumac.
- 使用Cochrane工具对偏差和使用I2统计数据对异质性的评估;用随机效应模型进行元分析.
主要成果:
- 包括7个RCT,570名参与者.
- 总胆固醇 (WMD: -10.01 mg/dL),甘油三 (WMD: -8.52 mg/dL) 和LDL-C (WMD: -9.25 mg/dL) 的显著降低.
- 在HDL-C (WMD:2.97 mg/dL) 中发现显著增加.
- 在干预持续时间≥12周时,观察到TG和TC的减少更大,HDL-C的增加更大.
- 每天低于3克的剂量显示TC和LDL-C的减少更大.
结论:
- 补充 Sumac 在改善脂质配置文件方面表现出显著的有效性.
- 它提供了一种有希望的自然方法来管理失脂症.
- 进一步的研究可能会优化 sumac 剂量和持续时间,以获得最大的心血管益处.
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