带有肌上皮特征的双相突肉瘤:一种独特的变体,偏爱脚部
Shahd S Almohsen1, Anthony M Griffin2, Brendan C Dickson1
1Department of Pathology and Laboratory Medicine, Mount Sinai Hospital and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Virchows Archiv : an international journal of pathology
|October 21, 2023
概括
这项研究详细介绍了脚部罕见的双相突肉瘤变体,其特征是肌皮质分化. 识别这种特定的瘤类型对于准确的诊断和患者管理至关重要.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
- 分子诊断学 分子诊断
背景情况:
- 突肉瘤 (SS) 呈现出多样化的组织学特征,构成诊断挑战.
- 经典的SS形态包括单相螺旋细胞或双相模式.
- 组织学变异可能会使准确的SS分类复杂化.
研究的目的:
- 描述一系列四个分子确认的双相突肉瘤病例.
- 为了突出非同寻常的肌上皮分化在远端下肢SS.
- 强调解剖部位对SS差异化的影响.
主要方法:
- 对四名患有双相足部SS的患者的病例综述.
- 瘤样本的组织病理学和免疫组织化学分析.
- 在所有情况下,SS18::SSX1/2聚变的分子确认.
主要成果:
- 这四种瘤都表现出双相形态,具有状细胞和上皮状元件.
- 在上皮区域观察到肌上皮的分化.
- 免疫组织化学显示了肌皮细胞标记物的可变表达 (基拉丁,EMA,p63,S100).
- 在所有病例中,SS18::SSX1/2融合证实了诊断.
结论:
- 双相突肉瘤可以表现出肌上皮分化,特别是在脚部.
- 解剖部位可能会影响突肉瘤的分化模式.
- 对这种变种的认识对于正确的诊断,治疗和预后至关重要.
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