在自闭症谱系障碍中与维生素相关的生物途径
Darlan Gusso1, Gustavo Ricardo Krupp Prauchner2, Alessandra Schmitt Rieder2
1Neuroprotection and Neurometabolic Diseases Laboratory (Wyse's Lab), Graduate Program in Biological Sciences: Biochemistry, Department of Biochemistry, Federal University of Rio Grande Do Sul (UFRGS), Rua Ramiro Barcelos, 2600-Anexo, Zip Code 90035003, Porto Alegre, RS, Brazil. Darlan.gusso@edu.pucrs.br.
Neurotoxicity research
|October 21, 2023
概括
本综述探讨了叶酸,维生素B12和维生素D在自闭症谱系障碍 (ASD) 中的作用. 它还探讨了怀孕期间营养的影响以及母亲压力与ASD风险之间的潜在联系.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 营养科学 营养科学
背景情况:
- 自闭症谱系障碍 (ASD) 的病因在很大程度上是未知的,具有潜在的遗传和环境影响.
- 怀孕期间的营养缺乏,特别是叶酸,维生素B12和维生素D,与中枢神经系统损伤和神经发育问题有关.
- 建议在怀孕初期补充叶酸 (FA),以预防神经管缺陷,而维生素B12和维生素D在认知功能,大脑发育和基因表达中发挥作用.
研究的目的:
- 审查有关叶酸,维生素B12和维生素D在ASD中的作用的当前文献.
- 讨论胎儿发育期间营养缺乏或营养过多对ASD风险的影响.
- 探索维生素补充研究中的潜在混因素,并提出皮质醇作为母亲压力,维生素状况和ASD之间的联系.
主要方法:
- 关于维生素 (叶酸,B12,D) 和ASD的最新研究的文献综述.
- 在妊娠期间对营养缺乏和过度补充的影响的分析.
- 探索维生素补充试验中的偏差以及母亲压力 (皮质醇) 的作用.
主要成果:
- 维生素B9 (叶酸),维生素B12和维生素D对于胎儿神经发育至关重要,并且与ASD有关.
- 怀孕期间的营养不平衡可能会影响ASD易感性.
- 受到皮质醇调节的孕产妇压力可能会调节维生素状况和ASD患病率之间的关系.
结论:
- 维生素叶酸,B12和D在怀孕期间对神经发育至关重要,可能会影响ASD风险.
- 需要进一步的研究来了解母亲营养,压力和ASD之间的复杂相互作用.
- 皮质醇可以作为连接维生素乱和ASD易感性的桥梁.
关键词:
自闭症谱系障碍 自闭症谱系障碍中枢神经系统中枢神经系统维生素 D 维生素 D 维生素 D 维生素 D这是维生素. B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12 B12这是维生素. B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B9 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B2 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B2 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B2 B1 B1 B1 B1 B1 B1 B1 B2 B1 B1 B1 B1 B1 B1 B2 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B1 B2 B1 B1 B1 B1 B1 B1 B1
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