在美国,血与帕金森病的相关性 (NHANES 2011-2020)
Zhaohao Zeng1,2, Yanmei Cen3, Xiaoguang Luo4,5
1Department of Neurology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518001, Guangdong, China.
Environmental science and pollution research international
|October 21, 2023
概括
较高的血水平与帕金森病 (PD) 的风险降低有关. 这种关联是非线性的,在较高度下观察到更大的风险降低,这表明潜在的保护作用.
科学领域:
- 营养神经科学 营养神经科学
- 环境健康 环境健康
- 流行病学 流行病学
背景情况:
- 是一种重要的微量元素,对细胞健康,免疫功能和炎症控制至关重要.
- 新兴研究表明,水平与帕金森病 (PD) 风险之间存在联系.
- 了解这种关系对于公共卫生和潜在的预防策略来说很重要.
研究的目的:
- 研究血度与美国成年人帕金森病 (PD) 患病率之间的关联.
- 探索水平与PD风险之间的剂量反应关系.
- 为了解在神经退行性疾病中的作用做出贡献.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (2011-2020) 的横截面分析.
- 包括15660名40岁以上的美国成年人.
- 应用后勤回归和限制立方线 (RCS) 模型来评估关联和剂量反应关系.
主要成果:
- 血度升高与帕金森病 (PD) 的患病率降低有关.
- 观察到一种非线性关系,在较高的水平下,风险降低更为显著.
- 约2.4μmol/L的拐点表明,超过这个度后,风险降低的程度正在下降.
结论:
- 较高的血水平可能会对帕金森病 (PD) 产生保护作用.
- 与对照组相比,PD患者的血水平往往较低.
- 需要进一步的前性研究来确认因果关系,并调查在PD患者中的作用.
关键词:
抗氧化剂 生物标志物血中的是血中的.跨部门调查 跨部门调查多变量物流回归研究国家健康和营养检查调查 (NHANES)氧化作用 氧化作用帕金森病 (PD) 是一种疾病.有限制的立方线 (RCS)更多相关视频
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