周围和中央自主神经系统在胰岛素样生长因子-1激活方面的互补作用,以预防脂肪肝疾病
Itsuo Nagayama1, Kenya Kamimura2,3, Takashi Owaki1
1Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757, Asahimachi-dori, Chuo-ku, Niigata, Niigata, 951-8510, Japan.
Hepatology international
|October 21, 2023
概括
神经系统调节胰岛素样生长因子-1 (IGF-1) 的释放,影响非酒精性脂肪肝疾病 (NAFLD) 的进展. 这一发现突出了IGF-1的作用.
科学领域:
- 神经内分泌学神经内分泌学
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 胰岛素样生长因子-1 (IGF-1) 在非酒精性脂肪肝 (NAFLD) 病原发生中发挥作用.
- 在NAFLD早期阶段,生长激素 (GH) -IGF-1轴的参与尚未完全理解.
- 这项研究调查了IGF-1对NAFLD和GH通过神经通路释放的影响.
研究的目的:
- 阐明IGF-1在NAFLD发展中的作用.
- 探索通过肝-大脑-肠轴的垂体腺体激活GH分泌的过程.
- 为了确定中央神经对这个过程的影响.
主要方法:
- 在野生型和黑色皮质素-4受体淘汰赛小鼠中评估了GH和IGF-1水平,这些小鼠患有饮食引起的NAFLD.
- 使用素阻止了外周自主神经系统,以评估肝-大脑-肠轴贡献.
- 测量了下丘脑脑衍生神经营养因子 (BDNF) 和皮质otropin释放因子 (CRH) 的表达.
主要成果:
- 在NAFLD小鼠模型中,GH和IGF-1水平增加.
- 肝脏脂肪透被抑制,即使有外围自主神经系统的阻塞,抑制胃 ghrelin.
- 周围自主阻断降低了下丘脑BDNF和CRH,导致GH和IGF-1的分泌,在淘汰小鼠中废除了效应.
结论:
- 神经系统介导的IGF-1释放对NAFLD病态恒温至关重要.
- 在NAFLD中IGF-1的作用表明了潜在的治疗应用.
- 肝-大脑-肠轴和中央神经对NAFLD中GH-IGF-1调节有显著的影响.
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