在甲状腺相关眼科病的葡萄糖皮质类药物治疗后,大脑的结构和功能发生变化
Qian Wu1, Jiang Zhou1, Wei Fang2
1Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China.
The Journal of clinical endocrinology and metabolism
|October 21, 2023
概括
甲状腺相关的眼科医症 (TAO) 导致大脑的结构和功能变化,特别是在视觉和情感领域. 葡萄糖皮质激素治疗有助于恢复一些大脑功能,但缺陷可能会持续.
科学领域:
- 神经成像是一种神经成像.
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
背景情况:
- 甲状腺相关眼病 (TAO) 是一种自身免疫性疾病,影响眼睛和潜在的大脑.
- 了解TAO的神经影响对于全面的患者护理至关重要.
研究的目的:
- 在葡萄糖皮质醇治疗前后对TAO患者的大脑结构和功能变化进行调查.
- 使用基于声素的形态测量 (VBM) 和静止状态的功能性MRI (ALFF,ReHo) 进行详细分析.
主要方法:
- 32名TAO患者和23名健康对照人接受了基线MRI扫描.
- 患者接受了静脉注射葡萄糖皮质激素治疗.
- 26名患者在治疗后3个月重新扫描,以评估使用VBM,ALFF和ReHo的治疗效果.
主要成果:
- 与对照人群相比,治疗前的TAO患者在额头区域的灰质体积 (GMV) 减少,在视觉和情绪处理区域的大脑活动发生变化 (ALFF,ReHo).
- 在治疗后,TAO患者表现出前带带状和中侧上额头回环中的GMV增加,以及状和上尾回环中的活动改善.
- 尽管得到了改善,但在治疗后仍然存在左轨道上上额头环中的一些GMV缺陷.
结论:
- TAO与结构和功能性大脑缺陷有关,特别是影响视觉和情绪大脑区域.
- 葡萄糖皮质激素治疗在TAO患者的部分恢复大脑功能和结构方面表现出有效性.
- 这些发现增强了对TAO复杂病理生理学和治疗结果的理解.
相关概念视频
Open Angle Glaucoma: Treatment
459
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
459
Glaucoma: Overview
599
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
599
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
122
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
122
Angle Closure Glaucoma: Treatment
536
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
536
Functions of Thyroid Hormones
2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K
Synthesis and Regulation of Thyroid Hormones
4.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.7K


