在日本环境和儿童研究中,母亲尿液中新烟类度与儿童发育之间的关联
Yukiko Nishihama1, Shoji F Nakayama2, Tomohiko Isobe2
1Japan Environment and Children's Study Programme Office, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan; Paediatric Environmental Medicine, Institute of Medicine, University of Tsukuba. 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
Environment international
|October 21, 2023
概括
这项研究发现,孕妇在怀孕期间暴露于尼可类药物 (NEO) 与4岁以下儿童发育迟缓之间没有显著的联系. 需要进一步的研究来证实这些关于儿童发育风险的发现.
科学领域:
- 环境健康 环境健康
- 发育儿科 发育儿科
- 毒理学 毒理学 毒理学
背景情况:
- 新兴研究表明,暴露于尼可类药物 (NEO) 可能会影响人类的发育.
- 然而,关于NEO暴露于儿童发育迟缓的特定风险的数据仍然有限.
研究的目的:
- 调查产前尼可类药物 (NEO) 暴露与4岁以下儿童发育之间的关联.
- 利用了来自日本环境和儿童研究 (JECS) 的数据.
主要方法:
- 在怀孕期间测量了四种NEO代谢物 (dm-ACE,CLO,DIN,THX) 的尿度.
- 使用日本年龄和阶段问卷 (J-ASQ-3) 评估儿童的发育情况,从6个月到4岁.
- 采用树木分布式滞后混合模型进行统计分析,共8538名参与者.
主要成果:
- 在50%以上的样本中检测到dm-ACE,CLO,DIN和THX的尿度.
- "解决问题"领域的潜在延迟率最高 (10.5%),为6个月.
- 没有发现母亲尿液中NEO代谢物水平与儿童发展结果到4岁之间有统计学意义的关联.
结论:
- 孕前暴露于研究中的新尼古丁类药物 (NEO) 并没有显著与儿童长达四岁的发育迟缓有关.
- 建议对不同人群进行进一步的客观评估,以验证这些关于 NEO 和儿童发展的发现.
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