林代谢塑造了瘤的微环境:从原沉积到免疫逃避
Emily J Kay1, Sara Zanivan2, Alessandro Rufini3
1CRUK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK.
Current opinion in biotechnology
|October 21, 2023
概括
林代谢支持癌细胞生长,并塑造瘤微环境 (TME). 准这种途径可能会增强癌症治疗和免疫疗法反应.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
背景情况:
- 氨酸代谢越来越多地被认为是癌症进展中的作用.
- 它影响癌细胞的增殖,生存和瘤微环境 (TME).
研究的目的:
- 阐明普罗林代谢在癌症中的多方面的作用.
- 突出其在癌症相关纤维细胞 (CAF) 和TME中的重要性.
- 探索针对林代谢作为一种抗癌策略的潜力.
主要方法:
- 这项研究回顾了有关各种癌症中proline代谢的现有文献.
- 它分析了参与普罗林合成和降解的生物化学途径.
- 它检查了proline代谢对癌细胞,CAF和TME的影响.
主要成果:
- 与癌症相关的纤维细胞 (CAFs) 使用proline生物合成产生原蛋白,这对细胞外基质 (ECM) 至关重要.
- 在CAF中改变的プロ林代谢会损害原沉积,阻碍瘤生长和转移.
- 氨酸代谢影响细胞内活性氧物种 (ROS) 水平,影响细胞因子的释放和免疫细胞透到TME.
结论:
- 林代谢是癌细胞行为和瘤微环境的关键调节者.
- 准CAF中的普罗林代谢是一个有前途的治疗途径.
- 调节プロ林代谢可以提高患者的治疗结果和免疫治疗的反应.
更多相关视频
07:39The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues
Published on: June 16, 2018
9.3K
09:52A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
Published on: September 20, 2016
10.4K
相关概念视频
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
01:27Tumor Immunotherapy
538
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
538
02:40Cancer Stem Cells and Tumor Maintenance
4.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K