基因倾向对更高良性前列腺特异性抗原水平的临床后果
Mingjian Shi1, John P Shelley1, Kerry R Schaffer2
1Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
EBioMedicine
|October 21, 2023
概括
对更高前列腺特异性抗原 (PSA) 水平的遗传倾向与45-59岁男性的诊断评估增加有关. 这表明遗传因素影响前列腺癌查途径,而不仅仅是癌症风险.
科学领域:
- 遗传学 遗传学是一种遗传学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 预防医学 预防医学
背景情况:
- 前列腺特异性抗原 (PSA) 水平可能会受到独立于前列腺癌风险的遗传变异的影响.
- 对于高PSA的遗传倾向和随后的前列腺癌诊断工作之间的关系仍然不清楚.
研究的目的:
- 调查是否有更高PSA水平的遗传倾向导致前列腺癌的诊断评估增加.
主要方法:
- 开发了111个与PSA水平相关的单核酸多态的多基因分数 (PGS).
- 3110名没有前列腺癌的男性 (45-70岁) 接受了PSA查.
- 在PGS和高PSA (>4 ng/mL),诊断代码,泌尿学接触和前列腺活检之间的关联被分析使用Cox比例危险模型,按年龄分层.
主要成果:
- 在45-59岁的男性中,PGS与PSA大于4ng/mL (HR=1.35),PSA诊断码升高 (HR=1.30),泌尿学评估 (HR=1.34) 和前列腺活检 (HR=1.35) 显著相关.
- 在60-70岁的男性中,效应大小较小,并且在统计学上不显著.
- 关联估计报告在PGS中每个标准偏差变化.
结论:
- 对更高PSA水平的遗传倾向与在年轻男性 (45-59岁) 中 PSA升高的临床评估有关.
- 这一发现突显了遗传因素对前列腺癌诊断途径的影响.
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