相关实验视频
Updated: Jul 12, 2025
04:56
Assessment of Social Transmission of Food Preferences Behaviors
Published on: January 25, 2018
8.0K
味觉受体类型1成员3中介于小鼠的饮食诱导的认知障碍
Keon-Hee Lee1, Jae Won Song2, Chong-Su Kim2
1Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Republic of Korea; Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.
Life sciences
|October 21, 2023
概括
西方饮食通过激活味觉受体类型1成员3 (TAS1R3) 来损害认知能力. 阻止TAS1R3可以防止饮食引起的认知衰退,这表明它是大脑健康的治疗目标.
科学领域:
- 神经科学是一个神经科学.
- 饮食科学 饮食科学
- 分子生物学分子生物学
背景情况:
- 长期的西方饮食 (WD) 消费,高和脂肪和糖,与认知障碍有关.
- 正确的分子机制驱动WD诱导的认知衰退仍然不完全理解.
- 味觉受体类型1成员3 (TAS1R3),对WD组件有反应,在大脑表达,特别是海马.
研究的目的:
- 调查TAS1R3在中介性认知障碍中的作用,这种障碍是由老鼠长期消费WD引起的.
- 在WD引起的认知功能障碍的背景下,阐明受TAS1R3影响的分子通路.
主要方法:
- 野生类型 (WT) 和Tas1r3淘汰 (KO) 的小鼠在18周内被食正常饮食 (ND) 或WD.
- 用新型物体识别和巴恩斯迷宫测试来评估认知功能.
- 用RNA测序和生物信息学分析来探索潜在的分子机制.
主要成果:
- 在WD上的WT小鼠与ND上的WT小鼠相比,表现出显著的认知障碍.
- 塔斯1r3KO小鼠没有表现出认知障碍,即使在长时间的WD养后.
- 脑部疾病诱导的认知障碍与海马体基因表达的改变有关,包括AMP激活蛋白激酶 (AMPK) 信号和Sirtuin 3表达的变化,氧化应激反应减少和KO小鼠的神经发生增加.
结论:
- TAS1R3在调解与WD消费相关的认知缺陷方面发挥着关键作用.
- 针对TAS1R3是一个潜在的治疗策略,可以预防或减轻WD引起的认知障碍.
相关概念视频
01:20Taste Buds and Receptors
2.1K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
2.1K
01:14Conditioned Taste Aversion
153
Conditioned taste aversion, also known as sauce béarnaise syndrome, is a phenomenon in which an individual develops an aversion to a certain food taste following a negative experience, typically illness. This form of aversion is a type of classical conditioning in which the taste of the food (conditioned stimulus, CS) is associated with the experience of illness (unconditioned stimulus, UCS).
A notable characteristic of conditioned taste aversion is that it often requires only a single...
A notable characteristic of conditioned taste aversion is that it often requires only a single...
153