亚托皮性疾病中的真菌生物组:诱导因素和触发因素
Thais Glatthardt1, Erik van Tilburg Bernardes1, Marie-Claire Arrieta1
1the Department of Physiology and Pharmacology, University of Calgary, Calgary; the International Microbiome Centre, Snyder Institute for Chronic Diseases, University of Calgary, Calgary; the Department of Pediatrics, Alberta Children Hospital Research Institute, University of Calgary, Calgary.
The Journal of allergy and clinical immunology
|October 21, 2023
概括
肠道真菌,或真菌生物组,显著影响早期的免疫发育和亚托皮性疾病的风险. 菌群中的干扰可以导致过敏敏感化和TH2细胞反应,突出显示真菌是预防和治疗的关键目标.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 过敏学 过敏学
背景情况:
- 以2型炎症,TH2细胞反应和高IgE为特征的亚托皮性疾病在全球范围内正在增加.
- 早期的肠道微生物组障碍与阿托皮性疾病的发病率上升有关.
- 虽然细菌已经得到了广泛的研究,但肠道真菌 (mycobiome) 在免疫发育和症中的作用正在得到认可.
研究的目的:
- 审查最近关于肠道菌群和宿主免疫系统在生命早期之间的相互作用的发现.
- 阐明真菌在免疫耐受性与敏感性中的作用,在阿托皮病的背景下.
- 突出肠道真菌作为潜在的瘤预防和治疗的目标.
主要方法:
- 关于肠道菌群及其与宿主免疫的关系的当前科学文献的综述.
- 在早期发育过程中研究真菌与宿主相互作用的研究分析.
- 综合证据,将mycobiome dysbiosis与过敏性疾病的发病症联系起来.
主要成果:
- 肠道菌群在生命早期与宿主免疫系统发生显著的相互作用.
- 菌失生症可以促进敏感化和TH2细胞反应,从而导致阿托皮.
- 菌菌生与免疫耐受性的发展有关.
结论:
- 肠道真菌是过敏疾病发展的核心参与者.
- 菌群生物组代表了在阿托皮病预防和治疗方面的新策略的有希望的目标.
- 对真菌与宿主免疫相互作用的进一步研究对于理解和管理过敏状况至关重要.
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