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血清维生素D与超声波定义的肝纤维化有关

Rong Jiang¹, Yichao Zhou², Lei Han³

¹Jiangsu Health Vocational College, Nanjing, Jiangsu 210000, China.

Clinics and research in hepatology and gastroenterology

|October 21, 2023

概括

在非酒精性脂肪性肝病 (NAFLD) 患者中,维生素D水平升高与晚期肝纤维化减少有关. 这种保护作用在男性,非肥胖个体和60岁以下的人群中被观察到.

科学领域:

肝病学肝病学是一种肝病学.
营养科学营养科学
公共卫生公共卫生

背景情况:

维生素D与肝纤维化严重程度之间的关系仍在争论中.
非酒精性脂肪肝 (NAFLD) 是一个日益严重的公共卫生问题.
了解影响NAFLD进展的因素对于有效管理至关重要.

研究的目的:

为了研究血清维生素D水平与美国成人NAFLD晚期肝纤维化之间的关联.
为了确定维生素D状态是否会影响超声波定义的晚期肝纤维化.

主要方法:

2017-2018年国家健康和营养检查调查 (NHANES) 数据的回顾性分析.
基于控制衰减参数 (CAP) 的NAFLD诊断≥274dB/m.
使用肝硬度测量 (LSM) 识别的高级纤维化 (F2) ≥8.2kPa.
使用了根据NHANES指南加权的多变量逻辑回归模型.

主要成果:

分析了1624名NAFLD患者;18.28%的人患有晚期肝纤维化.
血清维生素D水平升高与肝纤维化有负面关联 (OR=0.47,p=0.034).
亚组分析显示,男性 (OR=0.34,p=0.014),非肥胖个体 (OR=0.20,p=0.042) 和60岁以下的人 (OR=0.43,p=0.033) 中存在显著的反向关系.

结论:

血清维生素D的升高与NAFLD患者中晚期肝纤维化患病率较低有关.
这种保护性关联在男性,非肥胖个体和年轻参与者中尤为明显.
进一步的研究可能会阐明维生素D在缓解NAFLD进展中的作用.

关键词:

肝脏纤维化肝脏纤维化这是NAFLD.基于人口的调查调查.维生素D 维生素D是一种维生素.

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