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在恐惧灭绝之后,前额叶皮层和杏仁体之间的功能连接的发展变化

K S Zimmermann¹, R Richardson¹, K D Baker¹

¹School of Psychology, UNSW Sydney, New South Wales 2052, Australia.

Neurobiology of learning and memory

|October 21, 2023

概括

恐惧灭绝学习涉及在发育过程中改变的大脑路径. 这项研究表明,青少年大鼠的功能连接性降低,这可能解释了恐惧抑制功能受损.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
行为神经科学行为神经科学

背景情况:

杏仁体和前额叶皮层 (PFC) 经历了显著的发育变化,影响了情绪学习.
连接PFC和杏仁体的途径对于恐惧灭绝至关重要.
青少年对恐惧灭绝的损害表明这些电路的发育变化.

研究的目的:

调查与恐惧灭绝相关的中介PFC (mPFC) 到杏仁体功能连接的发育变化.
为了确定潜在的神经机制,青少年缺乏恐惧的潜在的神经机制.

主要方法:

在未成年,青少年和成年老鼠中使用逆行追踪剂 (Fluorogold),注入杏仁体.
评估了恐惧调节和灭绝训练.
在桃体投射mPFC神经元 (PL和IL区域) 中测量学习依赖可塑性 (pMAPK).

主要成果:

mPFC层II/III神经元以ipsilaterally向底侧杏仁体投射;层V神经元以双边投射.
在整个发育过程中,在前临界 (PL) -杏仁体路径中没有观察到与灭绝相关的可塑性变化.
桃体投射神经元V层的内膜 (IL) 层中与灭绝相关的可塑性随着年龄的增长线性地减少.

结论:

阴下皮层和杏仁体之间的功能连接显示出显著的发育变化.
这些与年龄相关的IL-桃体路径的改变可能会导致恐惧抑制和灭绝学习的发展变化.

关键词:

青少年时期青春期阿米格达拉的一个桃体.灭绝的灭绝灭绝的灭绝恐惧恐惧恐惧恐惧前额叶皮层前额叶皮层.

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