关于Carboxymethyl纤维素水凝的风湿学见解
Karolinekersin Enoch1, Anbumozhi Angayarkanni Somasundaram1
1Soft Matter Laboratory, Department of Physics and Nanotechnology, SRM Institute of Science and Technology, Kattankulathur - 603203, Tamil Nadu, India.
International journal of biological macromolecules
|October 21, 2023
概括
这项研究通过物理交叉连接使用Carboxymethyl纤维素和Carbopol开发了稳定,机械强的水凝. 优化的度显示了通过皮肤递送药物和组织工程应用的前景.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 材料工程 材料工程 材料工程
背景情况:
- 由于其含水量和机械性能,水凝对于组织工程和药物输送至关重要.
- 开发稳定,机械坚固的水凝,没有有毒的交叉连接剂或高成本仍然是一个重大挑战.
研究的目的:
- 用一种廉价的物理交叉连接方法制备和表征Carboxymethyl纤维素基水凝.
- 为了评估这些水凝的机械强度和粘弹性行为,这些水凝具有不同度的Carboxymethyl纤维素.
- 为了确定最佳的水凝配方,用于通过皮肤递送药物应用.
主要方法:
- 基于碳素甲基纤维素的水凝以不同的度 (1-5 wt/v%) 合成,同时保持固定的Carbopol度 (1 wt/v%).
- 物理交叉连接是通过Carbopol和Carboxymethyl纤维素之间的结实现的.
- 进行了风湿学分析,以评估机械性能,包括粘弹性行为和产量应力.
主要成果:
- 水凝的机械强度和粘弹性随着高度的碳氧甲基纤维素而增加.
- 含有3-4重/重%的碳甲基纤维素的水凝表现出分别为58.83Pa和81.47Pa的屈服应力,表明适合通过皮肤输送.
- 水凝显示出高热稳定性,保持结构完整度高达50°C.
结论:
- 建立了一种高效,具有成本效益的方法,使用碳氧甲基纤维素和碳波烯制造稳定,机械强的水凝.
- 开发的水凝具有生物医学应用的理想特性,特别是通过皮肤输送药物和组织工程.
- 这些发现突出了这些生物相容和稳定的水凝在先进的治疗应用中的潜力.
相关概念视频
01:15Dehydration Synthesis
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.Synthesis of carbohydratesSugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from one reactant...
01:20Aldehydes and Ketones with Water: Hydrate Formation
An oxygen-based nucleophile, like water, can undergo addition reactions with aldehydes and ketones. The reaction leads to the formation of hydrates, also referred to as 1,1-diols or geminal diols.
The formation of hydrates is a reversible reaction. Hydrate formation is influenced by steric and electronic factors accompanying the alkyl substituents on the carbonyl group: The rate of hydrate formation increases with a decrease in the number of alkyl groups attached to the carbonyl carbon. Hence,...
The formation of hydrates is a reversible reaction. Hydrate formation is influenced by steric and electronic factors accompanying the alkyl substituents on the carbonyl group: The rate of hydrate formation increases with a decrease in the number of alkyl groups attached to the carbonyl carbon. Hence,...
01:31Physical Properties of Carboxylic Acids
Carboxylic acids with lower molecular weight exhibit a sharp and unpleasant odor. They also have higher boiling and melting points than analogous compounds, such as aldehydes, ketones, and alcohols.