通过微生物功能潜力和胆酸代谢的变化,调节pectin对肠道屏障功能的作用
Chang Yin1, Xiaobin Wen1, Guoqi Dang1
1State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, P. R. China.
The Journal of nutritional biochemistry
|October 21, 2023
概括
素补充剂通过调节肠道微生物群和胆酸代谢,减少压力和增强肠道屏障功能,改善了断奶小猪的肠道健康.
科学领域:
- 动物营养 动物营养
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 断奶会导致小猪的压力和肠道问题,这是由于肠道和免疫系统的不成熟.
- 作为一种益生菌多糖,pectin通过改变微生物群落来影响肠道信号和功能.
研究的目的:
- 为了研究点补充剂对断奶小猪的肠道健康的影响.
- 分析点对肠道微生物群组成,胆酸代谢和肠道屏障功能的影响.
主要方法:
- 16只断奶小猪分为对照组和补充乳清素 (5%) 的组.
- 分析了血清D-乳酸盐,性酸酶,阴道杯细胞和基因表达 (MUC2,ZO-1,Occludin).
- 评估肠道微生物群组成和胆酸概况,包括酸物种.
主要成果:
- 素改善了肠道粘膜屏障功能,通过减少血清D-乳酸盐和性酸酶来表明.
- 玻璃杯细胞增加和MUC2,ZO-1和Occludin在阴茎中的表达.
- 改变了肠道微生物群,Enterococcus的数量减少,Lactobacillus,Streptococcus和Clostridium_sensu_stricto_1的数量增加;高水平的氧化酸物种.
结论:
- 食性点氨酸通过微生物群调节和胆酸代谢来增强肠道健康,从而有益于断奶小猪.
- 素补充剂通过减轻断奶压力,对生长和发育产生积极影响.
- 研究结果表明,点丁是一种有益的益生菌,可以改善肠道健康并管理断奶压力.
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