通过未打开的瓶子快速检测假冒的COVID-19疫苗的创新方法,使用手持式空间偏移拉曼光谱 (SORS)
Sara Mosca1, Qianqi Lin1, Robert Stokes2
1Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, UKRI, Harwell Campus, OX11 0QX, UK.
Vaccine
|October 21, 2023
概括
空间偏移拉曼光谱 (SORS) 提供了一种快速,非侵入性的方法,通过通过瓶壁验证辅助剂的身份来验证COVID-19疫苗的真实性. 这项技术可以检测伪造的疫苗,提高全球疫苗安全性和公众信任.
科学领域:
- 分析化学 分析化学
- 频谱学是一种光谱学.
- 公共卫生 公共卫生
背景情况:
- 劣质和伪造的疫苗对公众健康构成重大威胁,尤其是在COVID-19流行病等全球危机期间.
- 疫苗短缺为假冒产品创造了机会,破坏了安全性,有效性和公众信心.
研究的目的:
- 探索使用手持式空间偏移拉曼光谱 (SORS) 进行COVID-19疫苗的非侵入性认证的可行性.
- 通过分析未打开的瓶子来评估SORS在检测伪造疫苗方面的能力.
主要方法:
- 一项概念验证研究,使用手持SORS设备快速分析未打开的疫苗瓶.
- 通过瓶壁验证主导辅助剂的化学特征.
- 测试SORS与假冒疫苗的替代样本和真正的COVISHIELDTM疫苗批量进行测试.
主要成果:
- 通过疫苗瓶壁,SORS成功地通过非侵入性方法验证了主要辅助剂的化学特征.
- 该技术区分了真正的COVISHIELDTM疫苗样本和替代伪造的疫苗样本.
- 疫苗批量和制造地点之间的差异被发现是微不足道的.
结论:
- SORS提供了用于疫苗认证的分子指纹,补充了现有的安全功能.
- 该技术可快速部署用于查COVID-19和其他疫苗,以及液体药物.
- 手持式SORS设备为对抗伪造药物的非侵入性查提供了一个实用的解决方案.
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