蛋白质素化和NET形成不会导致A20/TNFAIP3突变小鼠的病理

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Karel F A Van Damme1,2, Pieter Hertens1,3, Arne Martens1,3

  • 1VIB, Center for Inflammation Research, Technologiepark 71, 9052, Ghent, Belgium.

Scientific reports
|October 21, 2023
PubMed
概括

A20突变不会通过蛋白质素化或中性粒细胞外细胞陷 (NETs) 引起自身免疫. PAD4 缺乏也未能防止A20突变小鼠的自身免疫,这表明这些途径在A20相关的自身免疫疾病中不是致病性.

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