在康复元分析中缺少证据的原因:一个横截面元研究研究
Stefano Giuseppe Lazzarini1, Marzia Stella Yousif2, Silvia Bargeri3
1IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy. slazzarini@dongnocchi.it.
BMC medical research methodology
|October 21, 2023
概括
近一半符合条件的随机对照试验被遗漏在康复元分析中,这可能会影响有效性调查结果. 改进报告和协议注册对于全面的证据综合至关重要.
科学领域:
- 医学研究 医学研究
- 基于证据的医学基于证据的医学.
- 生物统计学 生物统计学
背景情况:
- 随机对照试验 (RCT) 的系统审查对于干预有效性的证据至关重要.
- 在定量分析中遗漏的证据可以在系统审查中引入偏见.
- 本研究调查了康复后元分析中遗漏的RCT及其原因.
研究的目的:
- 评估在康复领域的元分析中遗漏的RCT的比例.
- 识别和分类从元分析中遗漏符合条件的试验的原因.
主要方法:
- 采用了一个横截面的元研究研究设计.
- 确定了在康复系统审查中主要结果的合格试验.
- 遗漏的试验被系统地记录下来,遗漏的原因被归类.
主要成果:
- 在131个元分析中的1761个合格试验中,717个试验 (40.7%) 被遗漏.
- 关键的遗漏原因包括"无法区分选择性报告和不充分规划" (39.3%) 和"不充分规划" (17%).
- 非英语语言或不提供全文占遗漏试验的11.7%.
结论:
- 相当一部分符合条件的试验被遗漏在康复元分析中.
- 报告不足,缺乏协议注册,缺乏核心成果集,导致证据遗漏.
- 提高报告标准和采用标准化结果措施是必要的,以改善证据综合.
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