在不同瘤部位开发和验证早期结肠癌的预后诺姆图:基于人口的研究
Sirui Zhu1, Jiawei Tu1, Wei Pei1
1Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
BMC gastroenterology
|October 21, 2023
概括
这项研究开发了预后诺基图,以根据瘤位置预测早期结肠癌 (EOCC) 的存活率. 这些模型有助于临床医生为EOCC患者量身定制治疗.
科学领域:
- 在瘤学瘤学.
- 癌症流行病学 癌症流行病学
- 生物统计学 生物统计学
背景情况:
- 在50岁以下的人群中,早期结肠癌 (EOCC) 发病率上升.
- 右侧和左侧结肠癌之间存在明显的临床和分子差异,但在EOCC中研究不足.
- 需要精确的预后工具,根据EOCC瘤位置量身定制.
研究的目的:
- 在EOCC中开发和验证总生存率 (OS) 和癌症特异性生存率 (CSS) 的预后名录模型.
- 根据瘤位置 (右侧,左侧,横侧) 区分预后因素.
主要方法:
- 利用了5588名EOCC患者的监测,流行病学和最终结果 (SEER) 数据库.
- 使用考克斯回归,C指数,ROC曲线,校准图和决策曲线分析 (DCA) 开发和验证了名ograms.
- 卡普兰-梅尔分析被用来比较低风险和高风险组之间的存活率.
主要成果:
- 识别了晚期,肝转移,不良评分,CEA升高,化疗和围神经入侵作为独立的预后因素.
- 诺米图表表现出良好的预测性能 (AUC>0.8) 和对3年和5年的OS和CSS的一致性.
- 在低风险和高风险组之间观察到显著的生存差异,验证了模型的预后价值.
结论:
- 成功开发了EOCC按瘤位置分层的精确的诺莫格拉姆模型.
- 这些名图为EOCC的临床决策和治疗指导提供了宝贵的支持.
- 促进对EOCC管理进行进一步的前性后续研究.
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