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创伤后声恢复:基于MSC的生物等价药的生物相容性和有效性

Mikhail Svistushkin¹, Anastasia Shpichka^2,3, Polina Bikmulina²

¹Department for ENT Diseases, Sechenov University, Moscow, Russia.

Stem cell research & therapy

|October 21, 2023

概括

这项研究表明,一种新的生物等价剂有效地恢复了声 (VF) 组织结构和机械特性. 再生医学方法在治疗VF痕方面表现有前途,改进了现有的方法.

科学领域:

再生医学是一种再生医学.
生物材料科学生物材料科学
耳鼻喉科耳鼻喉科耳鼻喉科

背景情况:

声 (VF) 痕病变在耳鼻喉科提出了挑战.
目前的治疗方法缺乏可预测的结果,并且无法恢复VF膜自身结构.
再生医学为改善VF痕治疗提供了潜力.

研究的目的:

评估一种用于治疗声道痕的新生物等价药物的安全性和有效性.
在子模型中评估生物等效的性能,慢性声损伤.

主要方法:

开发了一种由PEG纤维素水凝和介酶干细胞 (MSC) 组成的生物等价物.
生物等价物通过对老鼠的异型植入和对子的正型植入经过痕切除后进行测试.

主要成果:

生物等价物证明了生物相容性,低炎症反应和良好的耐受性.
ортотоп植入显示出减少出血,并促进痕原蛋白纤维组织类似于本地组织.
植入的MSC被局部化到缺陷区域,组织机械特性接近完整的VF.

结论:

开发的生物等价物是生物相容的,并且有效地恢复声组织.
这种再生方法在治疗声痕症方面具有显著的潜力.

关键词:

生物等价的生物等价.纤维素纤维素是一种纤维素.在生物体内,在生物体内.介质细胞层细胞是介质细胞层细胞.皮格纤维素-PEG纤维素是一种再生医学是一种再生医学.痕痕痕的意思组织工程是组织工程.声乐折叠声乐折叠声乐折叠声乐折叠

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