系统性免疫炎症标志物与莫亚莫亚病风险之间的关联:一个病例控制研究
Wei Liu1,2,3,4,5, Chenglong Liu1,2,3,4,5, Xiaofan Yu1,2,3,4,5
1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Annals of medicine
|October 21, 2023
概括
系统性免疫炎症标志物增加,包括中性粒细胞与淋巴细胞比率 (NLR) 和系统性免疫炎症指数 (SII),与莫亚莫亚病 (MMD) 的风险增加有关. 较高的NLR和SII水平与MMD风险和疾病进展相关.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 心血管科学 心血管科学
背景情况:
- 系统性免疫炎症标记 (NLR,PLR,LMR,SII) 与心血管和瘤疾病的预后有关.
- 莫亚莫亚病 (MMD) 已知有炎症关联,但这些特定标记物的作用尚不清楚.
研究的目的:
- 调查系统性免疫炎症标志物与MMD风险之间的关联.
- 分析这些标志物与MMD亚型和疾病阶段之间的关系.
主要方法:
- 一项涉及360名MMD患者和89名健康对照者的病例控制研究.
- 计算和分析与MMD风险和亚型相关的全身免疫炎症标记 (NLR,SII).
主要成果:
- 增加的MMD风险与较高的中性粒细胞与淋巴细胞比率 (NLR) (OR 1.237) 有关.
- 较高的NLR和SII四分位数显著增加了MMD风险 (NLR:OR 3.206;SII:OR 3.074).
- 结合NLR和SII显示,最高子组的MMD风险较高 (OR2.643);风险和阶段 (苏州阶段3-4) 与反转U形的NLR和SII水平相关.
结论:
- 系统性免疫炎症标志物 (尤其是NLR和SII) 的升高与患MMD的风险增加有关.
- 这些标志物可以作为MMD风险,亚型和疾病进展的新指标.
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