在可操作的非小细胞肺癌中使用免疫检查点抑制剂的新辅助疗法
1Ludwig-Maximilians-Universität München (LMU), University Hospitals, Department of Medicine V, Division of Respiratory Medicine and Thoracic Oncology, Thoracic Oncology Centre Munich, Member of the German Center for Lung Research (DZL), Munich, Germany.
Current opinion in oncology
|October 22, 2023
概括
新辅助免疫化疗改善了局部非小细胞肺癌 (NSCLC) 的病理反应和无事件生存,没有显著的毒性. 为了获得长期的结果,需要进一步评估.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 临床试验 临床试验
背景情况:
- 在局部非小细胞肺癌 (NSCLC) 手术后出现系统性复发是常见的,需要改进辅助或新辅助疗法.
- 免疫检查点抑制剂 (ICI) 在转移性NSCLC中表现有前途,促使人们对其在早期疾病阶段的作用进行调查.
结论:
- 新辅助免疫化学疗法增强了局部NSCLC的MPR和EFS率,特别是在晚期瘤和表达PD-L1.1的瘤中.
- 将ICI添加到新辅助化疗中并没有显著增加毒性.
- 需要进行长期跟踪和评估,以充分确定NSCLC中新辅助免疫化学疗法的益处.
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