在患有天生的免疫错误的患者接种COVID-19疫苗后的抗体产生
Maryam Nourizadeh1,2, Elham Feizabadi1,2, Milad Mirmoghtadaei1,2
1Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Iranian journal of immunology : IJI
|October 22, 2023
概括
在患有天生的免疫错误 (IEI) 的患者中,COVID-19疫苗显示抗体产生和中和减少,特别是那些抗体缺乏的人. 这表明需要对IEI患者的免疫策略进行修订,以确保充分保护.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- 关于COVID-19疫苗在患有天生的免疫错误 (IEI) 的人群中的有效性数据有限.
- IEI涵盖了一系列影响免疫系统的疾病,包括抗体缺陷,细胞缺陷和补充缺陷.
研究的目的:
- 在IEI患者中评估COVID-19疫苗接种后的抗体产生和功能性抗体反应.
- 为了比较IEI患者的疫苗反应与健康对照者的疫苗反应.
主要方法:
- 在接种疫苗后,分析了41名IEI患者和32名健康对照者的血清样本.
- 使用EUROIMMUN和Chemobind套件测量了抗体水平 (IgG抗RBD) 和中和抗体活性 (cVNT).
- 统计分析比较了IEI子组和对照组之间的反应.
主要成果:
- 与对照组相比,Ab缺乏症患者的抗体度和中和能力明显较低.
- 几乎一半的补体和细胞缺陷患者也表现出病毒中和功能受损.
- 在EUROIMMUN和Chemobind试验结果之间观察到很强的相关性.
结论:
- 在许多IEI患者中,COVID-19疫苗接种引起了低于最佳的抗体反应,特别是那些抗体缺乏的人.
- 目前的疫苗策略可能需要对IEI种群进行修改,以实现有效的免疫力.
- 需要进一步的研究,以优化针对具有天生的免疫错误的个体的疫苗接种方案.
相关概念视频
01:51Vaccinations
44.6K
Overview
44.6K
01:36Humoral Immune Responses
72.8K
Overview
72.8K
01:22Development of Immunocompetence
320
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
320
01:31Active versus Passive Immunity
663
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
Active Immunity
Active immunity refers to the resistance one develops...
663
00:42Cross-reactivity
31.2K
Overview
31.2K
01:23Immunological Memory
634
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
634