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一次性塑料餐具对人类肠道微生物群和代谢物的热暴露的影响:一项准实验性研究

Xue Zhang¹, Xiaoxue He¹, Degong Pan¹

¹Department of Epidemiology and Health Statistics, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 750004, China.

Journal of hazardous materials

|October 22, 2023

概括

在一次性塑料餐具 (DPT) 中食用热食物会改变肠道微生物群和新陈代谢. 来自DPT的微塑料暴露对健康有相当大的影响,影响中枢神经系统,能量和炎症.

科学领域:

环境健康环境健康
微生物组研究微生物组研究
毒理学毒理学毒理学

背景情况:

一次性塑料餐具 (DPT) 广泛用于提供热食品.
微塑料 (MPs) 从DPT入食品的潜在泄漏是一个越来越令人担忧的问题.
消费DPT对人类肠道微生物群和新陈代谢的影响仍未得到充分研究.

研究的目的:

为了研究在DPT中食用热食物对人类肠道微生物群和新陈代谢的影响.
量化微塑料暴露及其与观察到的生物变化之间的相关性.
评估DPT使用停止后这些影响的可逆性.

主要方法:

与暴露 (DPT) 和控制 (非DPT) 组进行准实验性研究.
参与者每天吃三顿热饭,持续一个月.
分析了微塑料 (LDIR) 和肠道微生物群 (16S rRNA) 的便样本.
分析代谢物 (LC-MS/MS) 的尿样.

主要成果:

与暴露组相比,暴露后组的便中的微塑料含量明显较低.
在暴露和暴露后组和对照组中观察到Actinobacteria,Proteobacteria,Firmicutes和Bacteroidota的丰度发生显著变化.
肠道微生物群和代谢物概况的变化与中枢神经系统影响,能量代谢和炎症有关.

结论:

一个月的DPT热暴露显著改变了人类肠道微生物群和新陈代谢.
观察到的变化表明潜在的不良健康影响影响神经功能,能量平衡和炎症反应.
需要进一步的研究,以充分阐明DPT微塑料暴露对健康的长期影响.

关键词:

一次性塑料餐具的一次性塑料餐具.我们的肠道微生物群.它的代谢物是代谢物.热暴露热暴露热暴露

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