母性炎症性肠病对胎儿心脏功能的影响:一个病例对照研究
Deniz Oluklu1, Derya Uyan Hendem1, Dilek Menekse Beser1
1Department of Obstetrics and Gynecology, Division of Perinatology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey.
胎儿心脏功能在患有炎症性肠病 (IBD) 的怀孕中发生变化. 较长的IBD持续时间与受损的胎儿透静功能相关,突出了对心脏发育的潜在风险.
科学领域:
- 心脏病学 心脏病学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 胃肠病学 胃肠病学
背景情况:
- 孕妇的炎症性肠病 (IBD) 可以改变母亲的炎症环境和血管健康.
- 这些母亲的变化可能会影响胎儿的心脏发育和功能.
研究的目的:
- 在因IBD而复杂的怀孕中评估胎儿心脏功能.
- 探索母体IBD持续时间和胎儿心脏参数之间的关系.
主要方法:
- 进行了一项前性病例控制研究.
- 包括19名患有IBD (性结肠炎或克罗恩病) 缓解的孕妇和52名健康的孕妇.
- 评估胎儿心脏功能使用心声回声学,与盲目分析.
主要成果:
- 患有IBD的母亲的胎儿表现出明显改变的右心室功能,包括下部E',E'/A',S',三环状平面缩 (TAPSE).
- 升高的E/E,心肌性能指数 (MPI) 和异体度放松时间 (IVRT') 表明透析功能受损.
- 孕产妇IBD持续时间与胎儿右心室扩张功能受损有很强的相关性 (r2高达0.780,p ≤0.001).
结论:
- 患有IBD的怀孕与胎儿透静心脏和静脉心脏功能的显著变化有关.
- 增加母体IBD持续时间与更高的胎儿心脏扩张功能受损的风险有关.
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