周眼和眼睛表面非黑色素瘤皮肤癌
Jette Hooper1, Kimberly Shao1, Paula W Feng2
1Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut, USA.
Clinics in dermatology
|October 22, 2023
概括
周眼和眼表面非黑色素瘤恶性瘤,如基底细胞癌和状细胞癌,需要专门的管理. 治疗方法各不相同,复发率高于皮肤相对应物,需要仔细考虑维护视觉功能.
科学领域:
- 眼科医生 眼科 眼科
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
背景情况:
- 周眼和眼皮表面非黑色素瘤恶性瘤,包括基底细胞癌 (BCC),状细胞癌 (SCC) 和眼皮表面状瘤 (OSSN),很少见,但需要专门的治疗策略.
- BCC是最常见的周期性恶性瘤 (80-96%),其次是SCC (5-10%).
- OSSN涵盖了从发育不良到侵入性SCC的范围,代表了最常见的眼睛恶性瘤.
研究的目的:
- 为了提供关于诊断,分期和管理的概述,眼皮和眼皮表面非黑色素瘤恶性瘤.
- 要突出与这些瘤相关的独特因素和较高的复发率,与皮肤对应物相比.
- 讨论目前和新兴的治疗方式,旨在维护视觉功能.
主要方法:
- 审查当前文献和建立的临床指导方针,用于眼皮和眼皮表面非黑色素瘤恶性瘤.
- 使用美国癌症联合委员会 (AJCC) 分类系统进行分期的讨论.
- 标准和高级治疗方案的概述,包括莫斯手术,医疗疗法和全身治疗.
主要成果:
- 莫斯微图手术是治疗周期性恶性瘤的标准治疗方法.
- 对OSSN的管理选择包括医疗疗 (5-FU,INF,MMC) 和"无触摸"外科切除.
- 系统疗法,如声波刺抑制剂 (BCC) 和EGFR/免疫检查点抑制剂 (SCC) 是晚期疾病的选择.
- 周眼和眼部恶性瘤的复发率超过了它们的皮肤同类的复发率.
结论:
- 周眼和眼睛表面非黑色素瘤恶性瘤需要量身定制的管理方法.
- 早期诊断和适当的治疗对于优化结果和保护视力至关重要.
- 目前正在进行的全身疗法研究为高级或复发病例提供了新的希望.
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