来自内性真菌Microdiplodia sp.的类植物. 和它们的抗炎作用
Yufang Bi1, Yihu Yu2, Houzong Yao3
1The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang 330022, China; College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China.
Fitoterapia
|October 22, 2023
概括
内生菌真菌 微型类真菌 sp. 来自Camellia sinensis的CJ01产生了新的 terpenoids. 一些化合物通过抑制巨细胞中氧化 (NO) 生产显示出抗炎作用.
科学领域:
- 自然产品化学 自然产品化学
- 药用化学 医学化学
- 菌类学 菌类学是指菌类学.
背景情况:
- 内部植物性真菌,如Microdiplodia sp. 这样的. CJ01,是生物活性化合物的来源.
- 香含有各种具有潜在药理性质的内菌微生物.
- 类是天然产品的大类,具有广泛的生物活性,包括抗炎作用.
研究的目的:
- 从内生菌真菌Microdiplodia sp.中分离和表征类植物. CJ01.01 这就是为什么.
- 为了评估分离的化合物的抗炎潜力.
- 发现具有治疗应用的新型化学实体.
主要方法:
- 使用染色学技术进行化学检测以进行分离.
- 通过核磁共振 (NMR) 和高分辨率质谱 (HRMS) 阐明结构.
- 使用电子循环二元化 (ECD) 计算和实验来确定绝对配置.
- 在体外抗炎试验中,使用脂聚糖 (LPS) 诱导的RAW 264.7巨细胞.
主要成果:
- 隔离了16种特类,其中包括5种新的埃雷莫菲兰类特类 (microdiplodins A-E) 和1种新的特类 (13-carboxymacrophorin A).
- 此外,还确定了7种已知的埃雷莫菲兰类类和3种已知的类类.
- 化合物3,4,14-16在LPS刺激的巨细胞中显示出中度抑制氧化 (NO) 生产.
结论:
- 在化学研究的Microdiplodia sp. CJ01导致了新型类的发现.
- 几个孤立的化合物表现出抗炎活性,表明潜在的治疗价值.
- 这项研究突出了来自Camellia sinensis的内菌作为新抗炎药物的来源的潜力.
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