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亚洲印第安人的巨型乳腺瘤:来自西印度的单中心体验
Sandeep Kumar1, Saba Samad Memon1, Anurag Ranjan Lila1
1Department of Endocrinology, Seth G.S. Medical College & King Edward Memorial Hospital, Mumbai, India.
Annales d'endocrinologie
|October 22, 2023
概括
巨型前乳腺瘤 (GPs) 主要影响男性,并且经常表现为质量影响. 多巴胺激动剂治疗在大多数患者中使益乳素正常化,单一治疗更好地保护激素轴.
科学领域:
- 内分泌学 在内分泌学.
- 神经外科 神经外科
- 在瘤学瘤学.
背景情况:
- 巨型前列腺瘤 (GPs) 是一种罕见的垂体瘤,占前列腺瘤的4.3%.
- 有限的文献存在,具体涉及来自印度的全科医生.
研究的目的:
- 描述亚裔印度患者中全科医生的临床,生化,放射和治疗结果.
- 分析一大群患有巨型前性瘤的患者的结局.
主要方法:
- 一个单一中心对84名患有巨型前乳腺瘤的患者进行了回顾性分析.
- 成人和儿童年龄组之间的比较,以及男性和女性之间的比较.
- 用多巴胺激动剂 (DA) 和多式疗法对治疗结果的评估.
主要成果:
- 队列 (n=84) 显示男性占主导地位 (76.2%),平均年龄为34.1岁;男性呈现较年轻.
- 常见的表现包括视力障碍 (91.6%),头痛 (84.5%) 和阴性腺 (98.7%).
- 在97.3%的患者中,多巴胺激动剂治疗使80%的患者的益乳素正常化,并将瘤大小降低了50%或以上. 然而,淋巴腺轴的恢复很差 (20%). 与多式疗法相比,DA单疗法显示出对下丘脑-垂体-甲状腺 (HPT) 和下丘脑-垂体-上腺 (HPA) 轴的更好保护.
结论:
- 巨型乳腺瘤表现为男性占主导地位,并且通常与质量效应症状有关.
- 多巴胺激动剂是有效的第一线疗法,用于使益生素水平正常化并减少瘤大小.
- 多巴胺激动剂单一治疗在保护淋巴腺,甲状腺和上腺功能方面似乎优于多式疗法.
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