沈莲提取物通过缓解先发性炎症来改善动脉样硬化
Shuxian Han1, Chunxia Nie1, Chunmiao Wang1
1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Journal of ethnopharmacology
|October 22, 2023
概括
沈莲 (SL) 提取物通过减少先发性炎症,有效治疗动脉样硬化. 这种中国药物抑制了血管前进性纤维细胞和平滑肌肉细胞的变化,为动脉样硬化提供了一种新的治疗方法.
科学领域:
- 心血管研究研究心血管研究
- 炎症生物学 炎症生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 沈莲 (SL) 提取物,来自Salvia miltiorrhizae和Andrographis paniculata,针对动脉样硬化的炎症.
- 现有的研究将SL成分的抗动脉样硬化作用与炎症联系起来,但随机炎症的作用仍然未得到充分研究.
- 这项研究调查了SL提取物通过解决先发性炎症来减轻动脉样硬化的潜力.
研究的目的:
- 阐明冒险性炎症在动脉样硬化进展中的作用.
- 为了确定沈莲 (SL) 提取物是否可以逆转由偶然性炎症介导的动脉样硬化发展.
主要方法:
- 在ApoE-/-小鼠的动脉动脉上使用LPS浸泡的线程创建了一个新的动脉硬化小鼠模型.
- 在第2,4和第12周进行了动态评估血管先发性纤维细胞 (VAF) 现型,增殖和原合成.
- 在体外研究中评估了VAF对LPS的反应以及对血管光滑肌细胞 (VSMCs) 的共同培养效应.
主要成果:
- 在动脉样硬化模型中,SL提取物显著降低了脂质含量,偶然性炎症和斑块形成.
- 在体内和体外,SL提取物逆转了LPS诱导的VAF表型转变,增殖,迁移和炎症分泌.
- SL提取物抑制了VSMC的表型转换和迁移,可能通过JAK2-STAT3-MMP2通路.
结论:
- 进发性炎症充当"外向"信号,加速动脉样硬化斑块的形成和血管损伤的严重程度.
- SL提取物通过减轻随机炎症来改善动脉样硬化.
- 治疗机制包括抑制VAF和VSMC的表型转变,增殖和迁移.
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