在中国老年人中,PM2.5及其成分暴露对内皮功能的短期影响
Rukun Chen1, Kai Zhang2, Xiaoguang Li3
1Faculty of Medicine, University of Southampton, Southampton, UK.
The Science of the total environment
|October 22, 2023
概括
暴露于细颗粒物 (PM2.5) 损害了内皮功能,特别是在老年人中. 黑碳成为影响血管健康的关键污染物,暴露后三天.
科学领域:
- 环境健康 环境健康
- 心血管研究研究心血管研究
- 毒理学 毒理学 毒理学
背景情况:
- 颗粒物 (PM2.5) 暴露与包括心血管疾病在内的不良健康结果有关.
- 流媒扩张 (FMD) 是早期内皮功能障碍的敏感指标,对于预测动脉样硬化心血管疾病至关重要.
- 了解PM2.5成分对内皮功能的具体影响对于公共卫生至关重要.
研究的目的:
- 调查老年人暴露于PM2.5及其组成部分和内皮功能 (FMD) 之间的关联.
- 确定哪些特定的PM2.5成分对口和口病有最显著的影响.
- 探索污染物暴露与内皮功能变化之间的时间关系.
主要方法:
- 分析了上海812名65岁及以上患者的数据.
- 利用多种统计模型来评估PM2.5及其组成部分 (黑碳,硫酸盐,有机物质,氨) 和口病之间的关系.
- 在暴露后的不同延迟时间 (lag3,lag4,lag5) 检查了暴露效应.
主要成果:
- 增加的PM2.5水平与内皮功能 (下部口病) 的降低有关.
- 黑碳被确定为影响口病的占主导地位的PM2.5成分,在3.
- 对于硫酸盐,有机物质和在lag4和lag5的结果是不确定的,但表明潜在的意义.
结论:
- 升高的PM2.5水平会对老年人内皮功能产生负面影响.
- 黑碳是影响血管健康的重要个体空气污染物.
- 需要进一步的研究来证实硫酸盐,有机物和作为独立污染物的健康影响.
相关概念视频
01:19The Effect of Aging on Tissues
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
01:23Chronic Obstructive Pulmonary Disease I: Introduction
Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
01:23Chronic Obstructive Pulmonary Disease II: Emphysema
Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...