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基于生理学的建模和西斯普拉丁药理动力学的跨物种预测

Xiaowei Zang1, Leonid Kagan1

  • 1Department of Pharmaceutics and Center of Excellence for Pharmaceutical Translational Research and Education, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.

Journal of pharmaceutical sciences
|October 22, 2023
PubMed
概括

一个新的生理学基础的药理动力学 (PBPK) 模型准确地预测了动物和人类中西斯的分布. 这一框架有助于理解的药理动力学和优化癌症治疗.

关键词:
全度量尺度缩放方法 (Allometric Scaling) 是一种全度量尺度缩放方法.这是一种抗癌药物.建模和模拟的模型和模拟.组织分布 组织分布

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Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
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