药物负载和聚合物分子量对打印片的3D微观结构的影响
Bjarke Strøm Larsen1, Eric Kissi2, Liebert Parreiras Nogueira3
1Department of Pharmacy, University of Oslo, Sem Sælands vei 3, 0371 Oslo, Norway.
概括
这项研究表明,药物负载和聚合物分子量显著影响3D打印平板电脑结构. 较低的分子量基甲基纤维素 (HPMC) 和较低的药物负载导致更一致的平板电池孔和更好的结构保真度.
科学领域:
- 制药技术 制药技术 制药技术
- 材料科学 材料科学 材料科学
- 聚合物科学 聚合物科学
背景情况:
- 三维 (3D) 打印提供了新的制药制造可能性.
- 控制3D打印平板电脑的微观结构对于药物性能至关重要.
- 基甲基纤维素 (HPMC) 是基于热挤出 (HME) 的3D打印的关键聚合物.
研究的目的:
- 调查药物负载和HPMC分子量如何影响3D打印片的结构.
- 为了评估HPMC丝体内无形普雷尼索隆的物理稳定性.
- 用X射线微计算机断层扫描来评估3D打印平板电脑的结构特征.
主要方法:
- 热挤出 (HME) 用于制备带有普雷尼索隆的HPMC纤维.
- 热重力测量分析 (TGA) 和X射线粉末衍射 (XRPD) 用于导线的特性.
- 用于3D平板印刷的化沉积建模 (FDM).
- 用于平板电脑结构分析的X射线微型计算机断层扫描 (微型CT).
主要成果:
- 普雷尼索隆在长丝中保持无形,药物负载高达10%,除了一种配方外,稳定性良好.
- 用较低分子量HPMC (HPMC 15LV) 打印的平板显示出较低的孔隙性和较小的孔隙尺寸.
- 药物负载对总毛孔度有很小的影响,但影响了沿平板高度的毛孔度变化.
- HPMC 15LV的结果是平板电脑与数字设计具有更高的结构相似性.
结论:
- 聚合物分子重量是影响3D打印平板电脑孔隙性和结构精度的关键因素.
- 药物负载影响毛孔分布,但与聚合物选择相比,对整体平板结构的影响较小.
- 这些发现对于优化用于制药应用的3D打印过程至关重要.
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