在身体 (不) 活跃的个体处方他类药物治疗与在他类药物治疗的患者处方体育活动:一个四个场景的实践方法
Blanca Gavilán-Carrera1, Alberto Soriano-Maldonado2, Juan Diego Mediavilla-García3
1Department of Internal Medicine, Virgen de las Nieves University Hospital, Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; PA-HELP "Physical Activity for HEaLth Promotion" Research Group, University of Granada, Granada, Spain; Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Pharmacological research
|October 22, 2023
概括
与他类药物相关的肌肉症状可能被夸大,并受到nocebo效应的影响. 本报告建议将体育活动 (PA) 与他类药物治疗结合起来,考虑个体患者的个人资料,以更好地管理心血管疾病的风险.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 运动医学 运动医学
背景情况:
- 对于降低心血管疾病 (CVD) 风险,他类药物被广泛使用.
- 类他类药物相关的肌肉症状 (SAMS) 可能导致治疗中止和不良心血管疾病事件.
- 诺塞博效应,而不是他类药物本身,可能会导致许多SAMS,PA指南往往忽略了抵抗训练和减少久坐行为.
研究的目的:
- 提出一个框架,同时处方他类药物治疗和体育活动 (PA).
- 针对常见的临床场景,涉及使用他类药物和不同水平的PA.
- 重新评估萨姆斯风险的概括性,从马拉松跑步到一般的PA,在他类药物使用者中.
主要方法:
- 对SAMS和nocebo效应的新兴证据的审查.
- 对当前PA指南在脂质管理中的分析.
- 开发一种新的,基于场景的方法,用于联合处方他类药物和PA.
主要成果:
- 有证据表明,nocebo效应对SAMS有着显著的贡献.
- 将高强度炼的研究结果推广到他类药物使用者的所有PA可能是不合适的.
- 目前的指导方针不充分地解决了抵抗训练和减少久坐行为.
结论:
- 需要一个量身定制的方法来整合PA与他类药物治疗.
- 同时处方应考虑患者的PA病史和他类药物治疗阶段.
- 这一战略旨在优化心血管疾病风险管理,同时尽量减少SAMS的担忧.
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