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Updated: Jul 12, 2025

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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基于伊米达佐[2,1-b]醇的胺-2,3-二氧化酶1 (IDO1) 抑制剂:基于结构的设计,合成,生物评估和对接研究

Rahul Singh1, Ravinder Kumar1, Ashalata Roy2

  • 1Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160014, India.

Bioorganic & medicinal chemistry letters
|October 22, 2023
PubMed
概括

研究人员设计了新型的化异环化合物,作为潜在的甲胺-2,3-二氧化酶1 (IDO1) 抑制剂. 这些化合物显示出有希望的IDO1抑制活性,并且无毒,为IDO1相关疾病提供了新的治疗策略.

关键词:
3-二氧化基酶的使用方法这是一种IDO1抑制剂.伊米达佐 (Imidazo) [2,1-b] 亚 (thiazole) 是一种亚的化合物.伊米达 (Imidazole) 是一种药物.印度醇胺-2 的含量.一-三甲是什么?

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