在皮层网络的拓学上,皮层下的影响与功能处理层次结构保持一致
Fabian Hirsch1, Afra Wohlschlaeger1
1Department of Diagnostic and Interventional Neuroradiology, Klinikum R.d.Isar, Technical University Munich, Ismaninger Str. 22, Munich 81675, Germany.
NeuroImage
|October 22, 2023
概括
下皮层结构显著影响大脑网络组织. 消除它们的影响使皮质网络更加集成,而不是分离,揭示了子皮质在大脑连接中的关键作用.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 脑部成像 脑部成像
背景情况:
- 人类大脑中的功能连接 (FC) 形成了独特的皮质网络.
- 皮层下结构对皮层-皮层FC的影响尚未得到充分探索.
- 丘脑和基底腺结合了来自多个大脑网络的输入.
研究的目的:
- 用图形理论评估皮质网络拓学上皮质下影响.
- 调查皮下影响如何影响功能连接模式.
- 了解皮层下和皮层大脑网络之间的相互作用.
主要方法:
- 分析了100名健康参与者的休息状态fMRI数据 (人类结合体项目).
- 应用多变量方法和图形理论工具.
- 使用分割样本复制数据集的验证.
主要成果:
- 皮质网络架构在考虑皮质下影响时变得不那么分离,更集成.
- "跨模"系统的集成程度更高,而"单模"网络的集成程度较低.
- 在去除皮下影响后,边缘系统表现出明显减少的连贯性.
结论:
- 下皮层结构在宏观皮层组织中起着整合作用.
- 与预期相反,消除皮下效应会增加整体网络集成.
- 这些发现为大脑网络中的子皮质-皮质相互作用提供了新的见解.
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