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透析设备细菌污染的五年趋势
Eiichi Osono1,2, Kazumi Honda1, Yuki Inoue1
1Koshigaya Ohbukuro Clinic.
Journal of microorganism control
|October 22, 2023
概括
床边血液透析设备中的细菌污染,特别是Methylobacterium spp.,尽管每天进行清洁,但仍可能存在,可能是由于生物膜的形成. 替换部件的灭菌对于防止新的污染事件至关重要.
科学领域:
- 微生物学 微生物学
- 生物医学工程 生物医学工程
- 感染控制 感染控制
背景情况:
- 床边的血液透析监测设备位于透析液灭菌过器的上游.
- 该设备的细菌污染对患者安全和透析液质量构成风险.
- 了解污染动态对于有效的感染控制策略至关重要.
研究的目的:
- 在五年内调查床边血液透析监测设备中的细菌污染模式.
- 为了确定主导的细菌物种及其在设备中的持久机制.
- 评估日常清洁和维护程序的有效性.
主要方法:
- 在五年内,每四周对26个透析设备单位进行细菌污染的监测.
- 在上游使用超过膜,以防止最初的细菌进入.
- 细菌物种的识别和基因定型,重点是生物膜的形成和部分更换后的污染.
主要成果:
- 最初的细菌污染是最高和最多样化的,随着时间的推移与Methylobacterium spp. 成为占主导地位.
- 尽管每天进行清洁和无菌技术,但仍检测到持续存在的细菌基因型,这表明生物膜形成.
- 在更换部件安装后发现了 Pseudomonas aeruginosa,这突显了新组件的灭菌需求.
结论:
- 为了管理内部透析液,需要定期评估透析设备中的生物负担.
- 生物膜的形成是血液透析设备内的细菌持久性的可能机制.
- 所有更换部件的灭菌对于防止新污染物如Pseudomonas aeruginosa的引入至关重要.
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