结构化戒酒支持计划与急性酒精性胰腺炎 (PANDA) 的现行实践:多中心集群随机对照试验研究协议
Noor J Sissingh1, Anne Nagelhout2, Marc G Besselink3
1Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, the Netherlands; Department of Research and Development, St. Antonius Hospital, Nieuwegein, the Netherlands.
一个结构化的戒酒支持计划可以防止在第一次发作后再次出现急性胰腺炎. 潘达试验将该计划与当前实践进行全国性研究.
科学领域:
- 胃肠病学 胃肠病学
- 成 药物 药物 药物 药物
- 临床试验 临床试验
背景情况:
- 酒精消费是复发性急性胰腺炎的主要危险因素.
- 目前的临床指南缺乏关于戒酒策略的具体建议.
- 潘达试验解决了预防胰腺炎复发的基于证据的干预措施的需要.
研究的目的:
- 调查结构化戒酒支持计划在预防复发性急性胰腺炎方面的有效性.
- 为了比较干预计划的结果与急性酒精性胰腺炎第一个发作的患者的标准护理.
主要方法:
- 全国集群随机优势试验 (PANDA试验).
- 医院随机分为结构化戒酒支持或现行实践.
- 纳入标准:由于有害饮酒而引起的急性胰腺炎的第一次发作 (AUDIT评分特定范围).
- 主要终点:急性胰腺炎在一年内复发.
- 二级终点:戒酒/减少饮酒,与酒精有关的疾病,死亡率,生活质量,QALY和成本.
主要成果:
- 这个部分不在所提供的摘要中.
结论:
- 这是第一个使用集群随机设计的多中心试验,用于评估结构化戒酒支持,以预防复发性急性胰腺炎.
- 这项研究旨在为治疗急性酒精性胰腺炎患者的新治疗策略提供证据.
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