中性粒细胞,中性粒细胞外陷和类风湿性关节炎:为临床医生提供最新的评论

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Beatriz Frade-Sosa¹, Raimon Sanmartí¹

¹Servicio de Reumatología, Hospital Clínic de Barcelona, Barcelona, Spain.

Reumatologia clinica

|October 22, 2023

概括

中性粒细胞外细胞陷 (NETs) 越来越多地被认为是它们在类风湿性关节炎 (RA) 发病过程中的作用. 研究表明,NET可能是RA活动和疾病监测的生物标志物.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学

背景情况:

类风湿性关节炎 (RA) 是一种全身性自身免疫性疾病,主要与适应性免疫系统失调有关.
新出现的证据强调了先天免疫系统,特别是中性粒细胞在RA病变发生过程中的重要作用.
2004年描述的中性细胞外细胞陷 (NETs) 参与了RA的自身免疫过程.

研究的目的:

审查中性粒细胞和NET在类风湿性关节炎中的作用.
讨论了解NETs参与RA自身免疫现象的最新进展.
探索NET作为RA活动和疾病监测的潜在生物标志物.

主要方法:

在类风湿性关节炎中对NET研究的文献综述.
对中性粒细胞激活标记物的研究分析.
检查周围血液的NET测定及其与RA活动的相关性.

主要成果:

NETs可能通过作为自身抗原的来源来促进RA的发病.
NETs和其他中性粒细胞激活标志物显示出RA活性生物标志物的潜力.
边缘血液中NETs的确定正在研究其与RA活动的关系.

结论:

中性粒细胞和NET在类风湿性关节炎的自身免疫机制中起着至关重要的作用.
网络是开发RA活性生物标志物和监测疾病进展的有前途领域.

关键词:

关节炎是一种类风湿性关节炎.网症 (NETosis) 是一种疾病.作为一个中性粒细胞.中性粒细胞外细胞陷 (NET)中性粒度的部分是中性粒度类风湿性关节炎类风湿性关节炎类风湿性关节炎通过细胞外中子细胞 (NET) 的干.

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