在5天内服用全剂量阿扎西蒂丁,而在7天内服用周末休息时服用全剂量阿扎西蒂丁:一项回顾性队列研究
Guilherme Sapinho1, Lídia Alves-Ribeiro2, Joana Infante3
1Serviço de Hematologia e Transplantação de Medula, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal; Laboratório de Genética, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
全剂量阿扎西提丁 (7 × 75 mg/m2) 用于更高风险的骨髓分裂综合征 (MDS) 显示了相似的生存结果,无论是在5天或周末休息的5天内服用. 这一发现支持了MDS患者灵活的服用时间表.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床药理学 临床药理学
背景情况:
- 阿扎西提丁是高风险骨髓分裂综合征 (MDS) 的关键治疗方法,但其标准的7天时间表对门诊治疗提出了后勤挑战.
- 为方便使用替代的5天和5+2天时间表,尽管在高风险的MDS中证据有限.
研究的目的:
- 在患有高风险MDS的患者中,通过5天计划与5+2天计划进行全剂量阿扎西蒂丁的疗效和安全性进行比较.
主要方法:
- 一个单一中心的回顾性队列研究,涉及100名患有高风险MDS的患者,接受全剂量阿扎西提丁 (7 × 75 mg/m2).
- 总体生存率和无急性髓性白血病生存率 (AMLFS) 用卡普兰-梅尔分析和考克斯模型进行了评估.
- 在49名患者的子样本中评估了感染率和输血负担.
主要成果:
- 在5天和5+2天方案之间,平均整体存活时间 (12.5个月与15.0个月;HR 0.95) 或AMLFS (HR 1.70) 没有显著差异.
- 在多变量分析中,阿扎西提丁的服用时间表不是感染或输血需求的预测指标.
结论:
- 在较高风险的MDS中,全剂量阿扎西蒂丁 (7 × 75 mg/m2) 给药是可行的,并且在5天和5+2天的方案中,可比的生存,感染和输血结果.
- 5+2天时间表提供了一个切实可行的替代方案,不影响患者的治疗结果,解决门诊护理的后勤挑战.
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