在新辅助疗法期间发展的肉类与食道腺癌患者的生存率降低有关
Katherine Pierce1, Prejesh Philips1, Michael E Egger1
1University of Louisville School of Medicine, Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, KY.
Surgery
|October 22, 2023
概括
在新辅助疗法期间患上肉可能会使接受手术的食道癌患者的生存率恶化. 这项研究强调了在手术前监测肌肉质量变化的重要性.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 外科手术的结果
背景情况:
- 肉,或肌肉损失,与癌症患者手术后的各种结果有关.
- 经过食道胃肠切除术的食道腺癌患者有患肉症的风险.
- 在新辅助治疗期间,萨科佩尼亚发展对存活率的影响尚未完全理解.
研究的目的:
- 为了确定在新辅助期内发生的肉类是否预测食道腺癌患者的术后死亡率.
- 分析了在诊断时和手术前与整体存活率之间的萨尔科佩尼亚状态之间的关联.
主要方法:
- 预期数据库查询食道腺癌患者进行食道胃肠切除术 (2014-2022年).
- 在诊断时和手术前使用第三腰椎横截面成像来评估形状.
- 总体存活时间的比较,基于肉症的发展和状态.
主要成果:
- 超过一半的患者 (50.7%) 在诊断时患有肉类;40%的非肉类患者在手术前发展了它.
- 与其他组相比 (47个和31个月;P=.02),手术前发展为肉类的患者的整体存活期 (18个月) 显著降低 (47个和31个月;P=.02).
- 无论是诊断性还是手术前的萨科佩尼亚单独都没有显著影响整体存活率;与癌症无关的死亡是常见的.
结论:
- 在新辅助期内发生的肉类可能与接受食道切除术的患者的整体存活率降低有关.
- 在新辅助疗法期间监测肉类症进展对于风险分层至关重要.
- 需要进一步的研究,以了解将肉症发展与不良结果联系在一起的机制.
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