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用抗体对抗的免疫代谢纳米粒子重塑内单核细胞

Chang Liu¹, Yanfeng Zhou¹, Daoxia Guo¹

¹State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|October 22, 2023

概括

这项研究引入了免疫代谢纳米粒子 (immeNPs) 来重编程瘤透免疫细胞.immeNPs增强了抗癌免疫力,并改善了耐药瘤的免疫治疗反应.

科学领域:

免疫学免疫学免疫学
纳米技术纳米技术
癌症生物学癌症生物学

背景情况:

瘤中的单核细胞 (MP) 由于脂质积累,经常采用亲瘤原生表型.
这会损害宿主对抗癌症的免疫防御.
重编程这些MP对于有效的癌症免疫疗法至关重要.

研究的目的:

设计包裹的免疫代谢纳米粒子 (immeNPs) 用于对内MPs进行协同重塑.
为了同时提供病毒RNA模拟物和脂肪酸氧化调节剂.
为了克服对当前癌症免疫疗法的耐药性.

主要方法:

开发的immeNPs被癌细胞膜伪装成,并与抗CD163抗体进行异位.
给药的immeNPs可以共同提供治疗有效载荷.
在瘤模型中分析了MP再极化和免疫细胞透.
评估了immeNPs与抗PD-1疗法结合的疗效.

主要成果:

内化 immeNPs 重新编程脂质新陈代谢并刺激先天免疫力.
实现了M2-to-M1巨细胞再极化和宽容性-免疫性树突细胞分化.
诱导细胞毒性T细胞透到瘤中.
在乳腺和卵巢瘤中克服了抗PD-1疗法的耐药性.

结论:

ImmeNPs有效地重塑瘤透的单核细胞.
这种策略增强了抗瘤免疫反应,克服了免疫疗法耐药性.
ImmeNPs提供了一种有希望的方法来扩大传统癌症免疫治疗的实用性.

关键词:

生物模拟纳米颗粒生物模拟纳米颗粒免疫代谢重塑免疫代谢重塑天生的免疫刺激天生的免疫刺激脂质代谢重编程脂质代谢重编程单核细胞是一种单核细胞.

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