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免疫微环境在患有子宫内膜异位症的患者中的重要性

Ioana Păvăleanu¹, Raluca Anca Balan, Adriana Grigoraş

¹Department of Morphofunctional Sciences I, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania; adriana.grigoras@umfiasi.ro, a_grigoras6600@yahoo.com, adriana.grigoras@umfiasi.ro, raluca12usa@yahoo.com, raluca.balan@umfiasi.ro.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

|October 23, 2023

概括

子宫内膜异位症涉及像巨细胞和T细胞这样的免疫细胞,CD68+巨细胞增加与受影响组织中的孕激素受体 (PR) 表达相关. 这突显了子宫内膜异位症的免疫依赖性.

科学领域:

生殖免疫学生殖免疫学
分子妇科学分子妇科学

背景情况:

子宫内膜异位症是一种依赖雌激素的慢性疾病,涉及免疫细胞,矩阵重塑,E-cadherin,β-catenin和类固醇激素受体.
免疫细胞,包括巨细胞和淋巴细胞,与子宫内膜异位症的进展,血管生成和侵袭有关.

研究的目的:

研究细胞免疫特征与子宫内膜异位症中E-cadherin,β-catenin,雌激素受体α (ERα) 和孕激素受体 (PR) 的表达之间的关系.
分析子宫内膜异位症患者的血清学参数和免疫组织化学 (IHC) 标志物之间的潜在关联.

主要方法:

从53名患者的子宫内膜异位症组织的组织学和免疫组织化学 (IHC) 分析.
免疫细胞密度 (CD4+,CD8+T细胞,CD68+巨细胞) 和蛋白质表达 (E-cadherin,β-catenin,ERα,PR) 的评估.
血清分析与IHC发现相关联.

主要成果:

在子宫内膜植入物中观察到的CD4+T细胞,CD8+T细胞和CD68+巨细胞的密度增加.
变量对E-cadherin,β-catenin,ERα和PR表达的上调调节.
在CD68 (巨细胞标记物) 和PR表达 (p<0.05) 之间发现了显著的正相关性.

结论:

子宫内膜异位症的特征是子宫内膜异位体植入物内的免疫细胞特征发生变化,特别是T细胞和巨细胞.
这些发现支持子宫内膜异位症作为一种具有复杂分子机制的免疫依赖性疾病.
进一步研究免疫疗法,如T细胞向免疫疗法,是有必要的.

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