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Updated: Jul 12, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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PI3K/AKT/mTOR信号通路和Sirtuin基因在慢性阻塞性肺病发展中的作用

G F Korytina1, L Z Akhmadishina2, V A Markelov1

  • 1Institute of Biochemistry and Genetics - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia Bashkir State Medical University, Ufa, Russia.

Vavilovskii zhurnal genetiki i selektsii
|October 23, 2023
PubMed
概括

这项研究研究了慢性阻塞性肺病 (COPD) 的遗传因素,发现SIRT1,SIRT3,SIRT6,PIK3R1和PTEN中的特定基因变异与COPD风险有关. 基因相互作用,特别是涉及PIK3R1和SIRT3的基因相互作用,显著增加了COPD易感性.

关键词:
在PI3K/AKT/mTOR信号通路中.细胞衰老 细胞衰老慢性阻塞性肺病 慢性阻塞性肺病氧化应激是一种氧化应激.这里是Sirtuinsins的所在地.

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