病例报告:克罗恩病患者恶性黑色素瘤,接受乌斯特基努马布治疗
Georgios Axiaris1, Alexandros Ioannou1, Marina Papoutsaki2
1Gastroenterology Department, Alexandra General Hospital, Athens, Greece, 11528, Greece.
F1000Research
|October 23, 2023
概括
炎症性肠病 (IBD) 的长期免疫抑制可能会增加皮肤癌的风险. 这一案例凸显了接受此类治疗的IBD患者需要警性皮肤学监测的必要性.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫调节剂是炎症性肠病 (IBD) 的标准.
- IBD患者面临肠道和肠外恶性瘤的风险增加.
- 抗IL12/23抗体乌斯特基努马布 (Ustekinumab) 的安全性概况普遍良好,尽管已有各种恶性瘤的报道.
研究的目的:
- 报告一个罕见的染色性恶性黑色素瘤病例在一个克罗恩氏病患者治疗ustekinumab.
- 强调与IBD的长期免疫抑制疗法相关的皮肤性恶性瘤的潜在风险.
- 强调需要对服用免疫抑制剂的IBD患者进行终身,细致的皮肤病监测.
主要方法:
- 一个42岁的男性克罗恩氏病患者的病例报告,具有广泛的治疗史.
- 详细的病史,包括以前的治疗方法 (阿扎西奥普林,因弗利西马布,阿达利穆马布) 和手术干预.
- 在 ustekinumab 治疗 3 年后诊断出转移性无色色恶性黑色素瘤.
主要成果:
- 患者患上了转移性色谱性恶性黑色素瘤,具有BRAF V600E突变.
- 黑色素瘤是在头皮发后发现的.
- 对黑色素瘤向治疗的初始反应是积极的.
结论:
- 在IBD患者的长期免疫抑制与皮肤性恶性瘤的风险增加有关.
- 对接受免疫抑制剂的IBD患者来说,仔细和终身的皮肤学评估至关重要.
- 这一案例强调了在IBD管理中识别和管理潜在的瘤风险的重要性.
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