最近S-F放射化学的进展用于 pozitron发射断层扫描
1Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China.
ACS omega
|October 23, 2023
概括
硫交换 (SuFEx) 点击化学使新硫-18F化合物能够用于正电子发射断层扫描 (PET) 成像. 这些进步提供了新的标记剂和试剂,补充了现有的碳-18F配体.
科学领域:
- 有机化学 有机化学
- 放射化学 放射化学是指辐射化学.
- 医疗成像医学成像
背景情况:
- 硫交换 (SuFEx) 化学已经使硫化合物的各种应用成为可能.
- 硫基化物,硫酸盐和硫基化物是SuFEx化学中的关键化合物.
- 开发用于PET成像的18F配体是一个重要的应用领域.
研究的目的:
- 审查硫-18F标记反应的进展.
- 为了突出在过去十年中用于PET成像的硫化物化合物的进展.
- 为了展示这些化合物作为18F标记剂,合成剂和化试剂的实用性.
主要方法:
- 关于S-18F标记反应的最新文献的综述.
- 使用SuFEx化学开发的关键18F化合物的分析.
- 讨论用于放射性标记的硫化物化学的突破.
主要成果:
- 在结合18F和硫化物化学方面取得了重大进展.
- 新的硫-18F化合物已经成为PET成像中的有价值工具.
- 这些化合物补充了传统的碳-18F配体,扩大了PET追踪器的选择.
结论:
- SuFEx化学提供了一个强大的平台,用于开发新的18F辐射追踪剂.
- 硫-18F化合物为PET成像应用提供了独特的优势.
- 该领域在过去十年中见证了实质性的进步,未来发现的潜力仍然存在.
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