合成,结构特征,抗氧化剂,细胞毒性活动和对 schiff 基Cu (II) 复合物的对接研究
Ghada N Rezk1, Ola A El-Gammal2, Salhah H Alrefaee3
1Department of Chemistry, Faculty of Science, Damietta University, Damietta 34517, Egypt.
Heliyon
|October 23, 2023
概括
研究人员合成了具有潜在抗癌和抗微生物特性的铜 (II) 水复合物. 这些复杂物表现出对瘤细胞的抵抗力,并抑制了细菌的生长,表明了治疗的前景.
科学领域:
- 协调化学 协调化学
- 材料科学 材料科学 材料科学
- 药用化学 医学化学
背景情况:
- 酸连接物是多功能合剂.
- 铜复合体表现出多样化的生物活动.
- 研究用于治疗应用的新型金属复合物.
研究的目的:
- 合成和描述新的铜 (II) 水复合物.
- 评估它们的生物活动,包括抗癌,抗氧化和抗菌作用.
- 探索它们的DNA结合相互作用和潜在的治疗点.
主要方法:
- 酸连接体 (HL) 和铜 (II) 复合物的合成 (1-3).
- 使用元素分析,光谱学 (红外,紫外,电子),XRD,热分析和分子导电性的表征.
- 生物测定:细胞毒性 (MCF-7,HepG-2),抗氧化剂 (DPPH),抗微生物 (S. aureus,E. coli),DNA结合 (粘度,吸收光谱).生物测定:细胞毒性 (MCF-7,HepG-2),抗氧化剂 (DPPH),抗微生物 (S. aureus,E. coli),DNA结合 (粘度,吸收光谱).
- 计算研究:密度功能理论 (DFT) 和分子对接 (SARS-CoV-2,乳腺癌目标).
主要成果:
- 成功合成了三种铜 (II) 水复合物.
- 光谱和分析数据证实了八面体几何和单基三联体体的行为.
- 复合体对MCF-7和HepG-2细胞系表现出显著的抗癌活性.
- 观察到有效的抗氧化剂和广泛的抗微生物活性.
- 综合体显示与小牛胸腺DNA的结合亲和力.
- DFT计算提供了对结构性质的洞察力.
- 分子对接表明与SARS-CoV-2和乳腺癌蛋白质的潜在相互作用.
结论:
- 合成的铜 (II) 水复合物具有有前途的抗癌,抗氧化和抗菌性质.
- 这些复合物具有作为治疗剂的发展潜力.
- 需要对其作用机制和体内疗效进行进一步的研究.
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